2. Signaling Pathways
  3. Immunology/Inflammation
  4. Interleukin Related

Interleukin Related

IL

Interleukin Related

Related Products

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Interleukins are a group of cytokines (secreted proteins and signaling molecules) that were first seen to be expressed by white blood cells (leukocytes). The function of the immune system depends in a large part on interleukins, and rare deficiencies of a number of them have been described, all featuring autoimmune diseases or immune deficiency. The majority of interleukins are synthesized by helper CD4 T lymphocytes, as well as through monocytes, macrophages, and endothelial cells. They promote the development and differentiation of T and B lymphocytes, and hematopoietic cells. Interleukin receptors on astrocytes in the hippocampus are also known to be involved in the development of spatial memories in mice.

Interleukin Related Isoform Specific Products:

Interleukin Related Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-101716R
    RP-54745 (Standard)
    		Inhibitor
    RP-54745 (Standard) is the analytical standard of RP-54745 (HY-101716). This product is intended for research and analytical applications. RP-54745 is an inhibitor of macrophage stimulation and interleukin-1 production, and a potential antirheumatic compound.
    RP-54745 (Standard)
  • HY-N6946R
    Mitraphylline (Standard)
    		Inhibitor
    Mitraphylline (Standard) is the analytical standard of Mitraphylline. This product is intended for research and analytical applications. Mitraphylline is the major pentacyclic oxindolic alkaloid presented in Uncaria tomentosa. Mitraphylline inhibits lipopolysaccharide-mediated activation of primary human neutrophils. Mitraphylline exhibits antiproliferative activity in human glioma and neuroblastoma cell lines. Mitraphylline can inhibit interleukin release in vivo.
    Mitraphylline (Standard)
  • HY-137225
    HTS07944
    		Inhibitor
    HTS07944 (HTS07944SC, C3) is a potent modulator of laminin receptor (37 LR). HTS07944 (HTS07944SC, C3) possesses anti-cancer activity in PC-3 cells and activates Caspase 3/7.
    HTS07944
  • HY-121303
    CK-102
    		Inhibitor
    CK-102 is an interleukin-1 (IL-1) inhibitor. CK-102 reduces mRNA synthesis. CK-102 does not inhibit DNA synthesis. CK-102 only slightly inhibits protein synthesis, or has no effect on it. CK-102 delays wound healing after ophthalmic surgery and prolongs the failure time of trabeculectomy fistulas. CK-102 inhibits lens protein-induced ocular inflammation at both early and late stages. CK-102 inhibits endotoxin-induced uveitis. CK-102 does not inhibit interleukin-1-induced uveitis. CK-102 can be used in research related to glaucoma filtration failure and uveitis.
    CK-102
  • HY-181485
    GPR68 antagonist 1
    		Inhibitor
    GPR68 antagonist 1 is a GPR68 antagonist with an IC50 of 81 nM. GPR68 antagonist 1 inhibits the mouse GPR68-mediated cAMP signaling pathway with an IC50 of 179 nM. GPR68 antagonist 1 alleviates disease symptoms in a dextran sulfate sodium (DSS) (HY-116282C)-induced mouse model of inflammatory bowel disease. GPR68 antagonist 1 is applicable to research related to inflammatory bowel disease.
    GPR68 antagonist 1
  • HY-113402B
    Gamma-glutamylcysteine ammonium
    		Modulator
    Gamma-glutamylcysteine ammonium (γ-Glu-Cys ammonium) is an orally active, blood-brain barrier permeable dipeptide. Gamma-glutamylcysteine ammonium activates AMPK, SIRT1, IL-4/STAT6, AC/cAMP/PI3K, IGF-1R/IRS1/PI3K, and Nrf2 signaling pathways; it inhibits NF-κB, JAK1/STAT1/3, MAPKs, cadmium-induced p38 MAPK, JNK, and PI3K/Akt signaling pathways. Gamma-glutamylcysteine ammonium regulates macrophage polarization, modulates the trafficking of CD36 and GLUT4, induces glutathione synthesis, improves metabolic dysfunction, reduces lipid deposition, ameliorates glucose homeostasis, inhibits apoptosis (Apoptosis), stabilizes mitochondria, suppresses lipid peroxidation, iron accumulation and ferroptosis (Ferroptosis), reduces ds-HMGB1 levels, reverses mechanical hyperalgesia, and alleviates hepatic lipid droplet formation. Gamma-glutamylcysteine ammonium is applicable to research related to inflammatory bowel disease, type 2 diabetes, cadmium-induced neurotoxicity, Alzheimer's disease, cerebral ischemia/reperfusion injury, neuropathy, and alcoholic liver disease.
    Gamma-glutamylcysteine ammonium
  • HY-A0132S14
    N-Acetyl-D-glucosamine-d3
    		Modulator
    N-Acetyl-D-glucosamine-d3 (N-Acetyl-2-amino-2-deoxy-D-glucose-d3) is deuterium labeled N-Acetyl-D-glucosamine. N-Acetyl-D-Glucosamine (N-Acetyl-2-amino-2-deoxy-D-glucose), the D isomer of N-acetylglucosamine, is an orally active monosaccharide derivative of glucose with anti-tumor and anti-inflammation properties. N-Acetyl-D-Glucosamine is also a bacterial metabolite, which is found in Escherichia coli. N-Acetyl-D-Glucosamine can induce yeast-mycelial conversion in Candida albicans. N-Acetyl-D-Glucosamine also enhances healing of cartilaginous injuries in rabbits.
    N-Acetyl-D-glucosamine-d<sub>3</sub>
  • HY-108013R
    Armillarisin A (Standard)
    Armillarisin A (Standard) is the analytical standard of Armillarisin A. This product is intended for research and analytical applications. Armillarisin A has the potential for the ulcerative colitis (UC) study. Armillarisin A increases IL-4 and lower IL-1β.
    Armillarisin A (Standard)
  • HY-19218
    RPR-106541
    		Inhibitor
    RPR-106541 is a 17-thiosteroid. RPR 106541 has potent glucocorticosteroid activity. RPR 106541 also has demonstrable effects on carbohydrate and lipid metabolism.
    RPR-106541
  • HY-N18954
    Heparin disaccharide III-S trisodium
    		Inhibitor
    Heparin disaccharide III-S trisodium (Compound SHH-7) is a heparin-derived disaccharide. Heparin disaccharide III-S trisodium acts as an inhibitor of spontaneous IL-8 and IL-1β secretion by intestinal epithelial cells. Heparin disaccharide III-S trisodium functions at the post-translational stage and does not reduce mRNA or intracellular mediator levels.
    Heparin disaccharide III-S trisodium
  • HY-B1971S1
    Deltamethrin-d6
    Deltamethrin-d6 (Decamethrin-d6) is deuterium labeled Deltamethrin. Deltamethrin (Decamethrin) is an orally active synthetic pyrethroid insecticide. Deltamethrin induces oxidative stress and results in inflammation and apoptosis via inhibiting Nrf2/HO-1 pathway. Deltamethrin has an anticancer effect by inducing apoptosis. Deltamethrin can be used extensively in pest control.
    Deltamethrin-d<sub>6</sub>
  • HY-111346R
    1-Linoleoyl Glycerol (Standard)
    		Inhibitor
    1-Linoleoyl Glycerol (Standard) is the analytical standard of 1-Linoleoyl Glycerol. This product is intended for research and analytical applications. 1-Linoleoyl glycerol is a LpPLA2 inhibitor. 1-Linoleoyl glycerol acts as a precursor for synthesizing various functional lipids, such as phospholipids. 1-Linoleoyl glycerol mitigates inflammation induced by Apolipoprotein CIII (reduction of IL-6).
    1-Linoleoyl Glycerol (Standard)
  • HY-N14780
    Pochonin D
    		Inhibitor
    Pochonin D ((+)-Pochonin D) is an inhibitor of heat shock protein 90 (Hsp90) with antiviral and anti-inflammatory activities. Pochonin D inhibits Hsp90, affects the homeostasis, folding and assembly processes of viral proteins, and reduces the replication capacity of viruses. Pochonin D is a copper ion carrier that can induce cuproptosis in triple-negative breast cancer cells by targeting PRDX1. Pochonin D reduces the infiltration of inflammatory cells, decreases the secretion of inflammatory cytokines such as TNF-α and IL-1β, and alleviates inflammatory responses. Pochonin D is a promising candidate for research on human rhinovirus (HRV) infection and cancer.
    Pochonin D
  • HY-W718206
    Cer (t18:0/26:0)
    		Activator
    Cer (t18:0/26:0) is a ceramide that can be used as an active ingredient in IL-8 production promoters and neutrophil activators. Cer (t18:0/26:0) can be used for pathogen infection research.
    Cer (t18:0/26:0)
  • HY-160121
    Patrinoside aglucone
    		Inhibitor
    Patrinoside aglucone (Compound 8) is an iridoid glucoside that can be isolated from the Valeriana tuberosa. Patrinoside aglucone has potent anticancer activity with G2/M phase tumor cell cycle arrest and apoptosis induction. Patrinoside aglucone also significantly inhibits the proliferation of cancer stem cells (such as MDA-MB-231 and U-251MG cells). Patrinoside aglucone has great anti-inflammatory activity by inhibiting NO release (IC50: 43.44 μM) and significantly reduces the level of TNF-α, IL-1β, IL-6, PGE2 and COX-2.
    Patrinoside aglucone
  • HY-171462
    SMW139
    		Inhibitor
    SMW139 is a selective allosteric antagonist of P2X7 receptor, with a Ki value of 32 nM for human P2X7R. The half-life of SMW139 in rat liver microsomes is 47 minutes. SMW139 can be used for inflammation, Alzheimer’s disease, multiple sclerosis study.
    SMW139
  • HY-129755
    CK-17
    		Inhibitor
    CK-17 is an orally active and potent anti-inflammatory agent. CK-17 shows potent inhibition of ocular inflammation induced by lens protein, endotoxin, and IL-1. The effects on IL-1-induced inflammation are about 2 fold more potent than Prednisolone (HY-17463).
    CK-17
  • HY-106087R
    IX 207-887 (Standard)
    		Inhibitor
    IX 207-887 (Standard) is the analytical standard of IX 207-887 (HY-106087). This product is intended for research and analytical applications. IX 207-887 is a novel antiarthritic agent which inhibits the release of interleukin-1 (IL-1).
    IX 207-887 (Standard)
  • HY-156436
    Anti-inflammatory agent 62
    		Inhibitor
    Anti-inflammatory agent 62 is an anti-inflammatory agent. Anti-inflammatory agent 62 alleviate Acetaminophen-induced hepatotoxicity in HepG2 by the regulation of inflammatory and oxidative stress pathways.
    Anti-inflammatory agent 62
  • HY-168561
    NLRP3-IN-58
    		Inhibitor
    NLRP3-IN-58 (Compound DS15) is an inhibitor for the activation of NLRP3 inflammasome with an IC50 of 3.85 μM, and inhibits 33% IL-1β release at a concentration of 10 μM.
    NLRP3-IN-58
Cat. No. Product Name / Synonyms Species Source
Cat. No. Product Name / Synonyms Application Reactivity
Interleukin Related Isoform Comparison

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